Invasive fungal infections and treatment (Simplified for residents)

Invasive fungal infections and treatment (Simplified for residents)

Antifungals: AEFA; Azoles, Echinocandins (Capsofungin, Micafungin and Anidulafungin), Flucytocine, Amphotericin B (Including Liposomal preparations)

Fungal infections: CA-CHM; Candida, Aspergillus, Cryptococcus, Histoplasmosis, Mucormycosis

Table		Antifungal agents
Fungal infections		Azoles	Echinocandins	Flucytocine	Amphotericin B
	Candida	+	+	+	+
	Aspergillus	-	+	-	+
	Cryptococcus	Fluconazole	-	+	+
	Histoplasmosis	Itraconazole	-	-	+
	Mucormycosis	Posaconazole	-	-	+

Candida albicans is sensitive to Fluconazole as well newer azoles (Posaconazole, Itraconazole and Voriconazole).

Non albicans candida (Candida glabrata and krusei) is not sensitive to Fluconazole but is effectively controlled by newer azoles such as Posaconazole, Itraconazole and Voriconazole.

Similarly Aspergillus is not sensitive to Fluconazole but newer azoles are effective against it (Posaconazole, Itraconazole and Voriconazole).

Flucytosine is effective against all candida and Cryptococci but not against aspergillus.

Posaconazole and Amphotericin B are effective against all fungi.  

You can also download the pdf file (https://drive.google.com/open?id=0B7fMzOzGc51UYUpvOVJDQVhlSm8) or the text file (https://drive.google.com/file/d/0B7fMzOzGc51ULVZ3dllUS2h4dG8/view?usp=sharing) from these links.

Comments and suggestions are welcomed.